The purpose of this study was to formulate and evaluate self pore forming osmotically controlled drug delivery system of urapidil. Urapidil is antihypertensive agent belonging to BCS class II with relatively short elimination half life 4.7 hr. Main objective to formulate this system was to achieve zero order release for urapidil. The present study was also aimed to develop a system that would reduce the frequency of dosing and thus increases patient compliance. Cellulose acetate was used as semipermeable membrane. Potassium chloride was used as pore forming agent. PEG4000 was used as plasticizer. Mannitol, sucrose, sodium chloride used as osmotic agents. This system was developed in two stages; (a) formulation of core tablets and (b) coating of core tablet. Core tablets were evaluated for dimension, weight variation, hardness, drug content, disintegration, invitro release, while coated tablets were evaluated for appearance, weight variation, thickness, hardness, in-vitro release study.
Loading....